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Prescription treatment is subject to clinical review. Availability and eligibility vary.

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For WomenWomen's HealthTestosterone / Estradiol Cream
Testosterone
Provider-guided care

Testosterone / Estradiol Cream

$75/ month · cream
Available plans
Start a free assessment

Treatment and plan are confirmed after your assessment.

Care starts with a clinician review

A licensed provider reviews your health history and determines whether treatment is appropriate for you.

What Is Testosterone/Estradiol Cream?

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How Testosterone / Estradiol Cream works

Reviewing Apexa care options on a laptop at homeStep 01

Step 1: Topical Application & Absorption

When you apply the testosterone and estradiol cream to your skin as directed, the hormones begin to absorb through the outer layers. The cream is formulated to allow these bioidentical hormones to pass through the skin barrier and enter the bloodstream. Clean, dry skin in areas with good blood flow (such as inner arms, thighs, or abdomen) provides optimal absorption. The lipophilic nature of these hormones allows them to dissolve through the skin's lipid layers efficiently.

A clinician reviewing care information on a laptopStep 02

Step 2: Entering the Bloodstream

Once absorbed through the skin, testosterone and estradiol enter the capillaries in the dermal layer and circulate through your bloodstream. This transdermal delivery system provides a steady, consistent release of hormones, mimicking the body's natural hormone production more closely than other delivery methods. The hormones travel throughout your body, binding to specific proteins that transport them to target tissues and organs where they're needed.

Opening an Apexa treatment package at homeStep 03

Step 3: Binding to Hormone Receptors

Testosterone and estradiol molecules bind to specific hormone receptors inside cells throughout your body. Once bound, they trigger genetic changes that affect protein production, influencing various body functions. Testosterone supports muscle mass, bone density, energy levels, and libido, while estradiol helps regulate mood, bone health, skin elasticity, and cardiovascular function. This binding process helps restore hormonal balance, potentially relieving symptoms associated with hormone deficiency or imbalance.

How to get Testosterone / Estradiol Cream online

From your first assessment to the next step in your care.

Opening an Apexa care package at home
  1. 01. Tell us about you

    Complete an online assessment about your goals, health history, and current routine.

  2. 02. Connect with a provider

    A licensed provider reviews your information and determines whether treatment is appropriate for you.

  3. 03. Begin care, if prescribed

    Review your treatment plan and use your patient account to manage consultations, orders, and messages.

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Learn more about this treatment and what to expect from your care.